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Hinxton, United Kingdom

The European Molecular Biology Laboratory (EMBL) is Europe’s flagship laboratory for the life sciences, with more than 80 independent groups covering the spectrum of molecular biology. EMBL is international, innovative and interdisciplinary – its 1600 multinational employees operate across six sites: the main laboratory in Heidelberg and outstations in Barcelona, Grenoble, Hamburg, Hinxton (the European Bioinformatics Institute; EMBL-EBI), and Rome. Founded in 1974, EMBL is an intergovernmental organisation, funded by public research monies from its 25-member states and two associate members, Argentina and Australia. The cornerstones of EMBL’s mission are to: perform basic research in molecular biology; train scientists, students and visitors at all levels; offer vital services to scientists in the member states; develop new instruments and methods in the life sciences and actively engage in technology transfer activities; and integrate European life science research.

The European Bioinformatics Institute (EMBL-EBI), the UK outstation of EMBL, helps scientists realise the potential of ‘big data’ in biology by providing freely available data and bioinformatics services to all facets of the scientific community. This includes sophisticated multi-dimensional statistical models for genotype to phenotype associations, single cell genomics, cancer genomics, phylogenetics, infectious disease genomics, deep learning, and structural biology. Many of the EMBL-EBI managed databases are deposition resources for the data that will be utilised within this project.

Project Contributions

The primary tasks of the European Bioinformatics Institute (EMBL-EBI) within the FindingPheno project relate to WP2, and to serve as the data coordinator. The main objective of EMBL-EBI’s tasks are to ensure uniform access to data and computing platforms across the project, and obtain genotype-phenotype associations on case study systems. In addition, EMBL-EBI will implement an iterative feedback mechanism to provide validation and improvement of models developed in WPs 3-5 by applying the models to multi-omics data from the case studies. Finally, EMBL-EBI will develop a solution to enable the sharing of the projects data outputs and how these results may be consumed by relevant EMBL-EBI resources.

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